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Butyrate and IBD: Can This Gut-Friendly Molecule Help?

What is Butyrate?

Butyrate is a short-chain fatty acid (SCFA) produced when gut bacteria ferment dietary fiber in the colon. It serves as a primary energy source for colon cells (colonocytes) and plays a key role in: Reducing inflammation by modulating immune response; Strengthening the gut barrier to prevent leaky gut; Balancing gut microbiota and supporting beneficial bacteria; and, Regulating metabolism and energy production in the intestines.


The Role of Butyrate in IBD

Through research, we do not completely know yet, but some evidence has proven that since individuals with IBD have gut inflammation, microbiome imbalances, and a weakened gut lining, butyrate may help.


Can You Increase Butyrate Levels Naturally?

So, if butyrate could help, what can you do to get more?

Eat More Fiber – Resistant starches and fermentable fibers (found in bananas, oats, legumes, and whole grains) help gut bacteria produce more butyrate.

Include Prebiotics – Foods like garlic, onions, and apples feed butyrate-producing bacteria.

Probiotics – Some probiotic strains, like Clostridium butyricum, enhance butyrate production.

Consider Dairy & Fermented Foods – Full-fat dairy and butter naturally contain small amounts of butyrate.


Final Thoughts: Is Butyrate a Potential IBD Ally?

While butyrate isn’t a cure for IBD, some research suggests it plays a protective role in gut health, reducing inflammation and strengthening the intestinal barrier. Increasing butyrate naturally through diet, probiotics, or supplements could help some IBD patients better manage symptoms and support long-term gut health.

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